SCHEMBL30044875

SCHEMBL30044875

Cn1nc(-c2ccc(C(F)(F)F)cc2)c2c1CN(C(=O)c1ccc(C3(O)COC3)cc1)C2

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 2/20 0.40
▸ KCNK3 O14649 3/20 0.40
▸ BRD4 O60885 2/20 0.40
▸ CREBBP Q92793 2/20 0.40
▸ KCNH2 Q12809 5/20 0.38
▸ SLC6A7 Q99884 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ SPTLC1 O15269 1/20 0.37
▸ SCN9A Q15858 1/20 0.37
▸ EPHX2 P34913 2/20 0.36
▸ MKNK1 Q9BUB5 1/20 0.35
▸ MKNK2 Q9HBH9 1/20 0.35
▸ STAT3 P40763 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577483 0.85 P2RX7 (0.40) P2RX7BRD4CREBBPKCNH2SLC6A7
SCHEMBL29844034 0.83 KCNK3 (0.56) KCNK3
SCHEMBL28818558 0.78 KCNK3 (0.48) P2RX7KCNK3BRD4CREBBPSPTLC1
SCHEMBL24529929 0.77 MEN1 (0.58) SLC6A7MEN1HPGDTSHRKMT2A
SCHEMBL23577559 0.74 USP7 (0.38) KCNH2SLC6A7MEN1HPGDTSHR
SCHEMBL29844006 0.74 MEN1 (0.55) MEN1HPGDTSHRKMT2AEPHX2
SCHEMBL29844211 0.74 CTSS (0.46) P2RX7KCNK3BRD4CREBBPSPTLC1
SCHEMBL29844016 0.74 NAMPT (0.44) KCNH2SLC6A7MEN1HPGDTSHR
SCHEMBL23577519 0.73 EPHX2 (0.39) KCNH2SLC6A7MEN1HPGDTSHR
SCHEMBL23605612 0.73 HPGD (0.42) SLC6A7MEN1HPGDTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA ZYDUS LIFESCIENCES LIMITED (IN) 2023-03-23 — — US claimed
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA ZYDUS LIFESCIENCES LIMITED (IN) 2023-03-23 — — US disclosed
EP-4081509-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA Zydus Lifesciences Limited (IN) 2022-11-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA PCSK9, CETP, LCAT P2RX7 4322/4885KCNK3 2642/4885BRD4 3543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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