SCHEMBL30048044

SCHEMBL30048044

ClCc1ccnc(Cl)c1CCl

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.34
LMNA P02545 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP3A4 P08684 1/20 0.31
MAPT P10636 1/20 0.31
APEX1 P27695 1/20 0.31
MAPK1 P28482 1/20 0.31
PMP22 Q01453 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15231682 1.00 KMT2A (0.34) KMT2ALMNANPSR1ALDH1A1SMN1; SMN2
SCHEMBL25184014 0.79 MPO (0.37) LMNAALDH1A1SMN1; SMN2CYP3A4MAPT
SCHEMBL6178552 0.79 KMT2A (0.35) KMT2ALMNANPSR1ALDH1A1CYP3A4
Hydrochloric Acid SCHEMBL31150968 0.77 MPO (0.36) LMNAALDH1A1SMN1; SMN2CYP3A4MAPT
SCHEMBL4104847 0.77
SCHEMBL20752742 0.76 NOS2 (0.44) KMT2ALMNANPSR1ALDH1A1SMN1; SMN2
SCHEMBL25184024 0.76 TDP1 (0.38) LMNAALDH1A1SMN1; SMN2
SCHEMBL16752355 0.76 ALDH1A1 (0.31) KMT2ALMNAALDH1A1SMN1; SMN2CYP3A4
SCHEMBL6179345 0.76 KMT2A (0.38) KMT2ANPSR1ALDH1A1
SCHEMBL24743981 0.76 KMT2A (0.33) KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115298176-A Compounds and their use in the treatment of bacterial infections 豪夫迈·罗氏有限公司 2022-11-04 CN disclosed