Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP4 | P49662 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | CASP9 | P55211 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30704873 | 1.00 | CASP3 (0.62) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL753100 | 0.85 | CES1 (0.55) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL29704375 | 0.85 | CES1 (0.55) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL18699211 | 0.85 | PIM1 (0.61) | CASP3CUL4ACES1TTRACHE | |
| SCHEMBL31419918 | 0.81 | CASP3 (0.62) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL9029012 | 0.78 | CASP3 (0.65) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL29403414 | 0.78 | CASP3 (0.65) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL15145704 | 0.78 | ACHE (0.56) | CUL4ACES1ACHEALDH1A1ALDH2 | |
| SCHEMBL21001752 | 0.78 | ALDH1A1 (0.65) | CUL4ACES1ACHEALDH1A1ALDH2 | |
| SCHEMBL6324792 | 0.78 | CA1 (0.56) | CASP3CUL4ACES1TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | claimed |
| CN-109384769-A | A kind of synthetic method of R configuration 3- substitution -3- hydroxyl oxidized indole compounds | 陕西师范大学 | 2019-02-26 | — | — | CN | claimed |
| CN-101503404-A | Preparation of 3-substituted-3-hydroxy-indole-2-ketone bis-heterocyclic derivative | UNIV EAST CHINA NORMAL (CN) | 2009-08-12 | — | — | CN | claimed |
| CN-118878450-A | C3-trifluoropropionyl oxydation reaction of N-substituted indole | 湖南科技职业学院 | 2024-11-01 | — | — | CN | disclosed |
| CN-118406000-A | Process for preparing 3-aminoindol-2-one derivatives | 南昌大学 | 2024-07-30 | — | — | CN | disclosed |
| CN-111423351-B | Chiral copper compound and preparation method and application thereof | 中国科学技术大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-113943309-B | Indolospiro [ benzofuran-2, 2' -pyrrolidine ] compound, preparation method thereof and application thereof in preventing and treating plant viruses | 江苏大学 | 2023-11-10 | — | — | CN | disclosed |
| EP-3728232-B1 | NOVEL QUINOLONE COMPOUNDS AS INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND/OR AS BCL6 DEGRADERS | ONTARIO INSTITUTE FOR CANCER RES OICR (CA) | 2023-08-30 | — | — | EP | disclosed |
| EP-3728232-B1 | NOVEL QUINOLONE COMPOUNDS AS INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND/OR AS BCL6 DEGRADERS | ONTARIO INSTITUTE FOR CANCER RES OICR (CA) | 2023-08-30 | — | — | EP | disclosed |
| CN-111433195-B | Pyridone derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-112898311-B | Indole spiro pyridocoumarin compound and preparation method and application thereof | 江苏大学 | 2022-06-21 | — | — | CN | disclosed |
| WO-2010053606-A2 | SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2010-05-14 | — | — | WO | disclosed |
| CN-101503404-A | Preparation of 3-substituted-3-hydroxy-indole-2-ketone bis-heterocyclic derivative | UNIV EAST CHINA NORMAL (CN) | 2009-08-12 | — | — | CN | disclosed |
| WO-2009039553-A1 | BENZOTHIAZOLE COMPOUNDS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2009-04-02 | — | — | WO | disclosed |
| EP-0432648-B1 | Isatine derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5198461-A | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-30 | — | — | US | disclosed |
| US-5192792-A | Isatine derivatives, and their method of use | WARNER-LAMBERT COMPANY (US) | 1993-03-09 | — | — | US | disclosed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | disclosed |
| EP-0503349-A1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-09-16 | — | — | EP | disclosed |
| EP-0432648-A2 | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1991-06-19 | — | — | EP | disclosed |