Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
| ▸ | TEC | P42680 | 1/20 | 0.31 |
| ▸ | TXK | P42681 | 1/20 | 0.31 |
| ▸ | BMX | P51813 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2989173 | 0.86 | CCR5 (0.35) | TSHRALDH1A1 | |
| SCHEMBL1801331 | 0.82 | CYP2C19 (0.43) | TSHRALDH1A1GAAMAPTNPSR1 | |
| SCHEMBL2940782 | 0.79 | GPR183 (0.40) | ALDH1A1GAAMAPTNPSR1 | |
| SCHEMBL1801681 | 0.79 | GPR183 (0.40) | ALDH1A1GAAMAPTNPSR1 | |
| SCHEMBL1799013 | 0.76 | CHRM1 (0.34) | DPP4CHRM1CHRM4MAPT | |
| SCHEMBL1799977 | 0.76 | AURKA (0.41) | TACR1TSHRP2RX7CHRM4ALDH1A1 | |
| SCHEMBL1799811 | 0.75 | KMT2A (0.43) | TSHRDPP4ALDH1A1GAA | |
| SCHEMBL3917088 | 0.73 | CCR5 (0.39) | TACR1TSHRDPP4BRD4 | |
| SCHEMBL2989339 | 0.71 | CXCR3 (0.35) | TSHRALDH1A1GAA | |
| SCHEMBL3006559 | 0.71 | CCR5 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |