Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.47 |
| ▸ | DRD4 | P21917 | 9/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056768 | 1.00 | DRD2 (0.47) | DRD2DRD4SIGMAR1MCHR1HSD11B1 | |
| SCHEMBL30056061 | 0.94 | SIGMAR1 (0.53) | DRD4SIGMAR1MCHR1HSD11B1CXCR4 | |
| SCHEMBL30057602 | 0.92 | HSD11B1 (0.46) | DRD2DRD4SIGMAR1MCHR1HSD11B1 | |
| SCHEMBL30056436 | 0.86 | DRD2 (0.46) | DRD2DRD4SIGMAR1MCHR1HSD11B1 | |
| SCHEMBL30056726 | 0.86 | DRD2 (0.46) | DRD2DRD4SIGMAR1MCHR1HSD11B1 | |
| SCHEMBL30057558 | 0.81 | MCHR1 (0.48) | DRD4SIGMAR1MCHR1CXCR4 | |
| SCHEMBL30056206 | 0.80 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL30611774 | 0.80 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL30032447 | 0.79 | HSD11B1 (0.43) | DRD2DRD4MCHR1HSD11B1FAAH | |
| SCHEMBL21765961 | 0.78 | NTRK1 (0.46) | SIGMAR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112805062-B | Imidazo [1,2-b ] pyridazines as Trk inhibitors | 博善人工智能生物科技有限公司 | 2024-06-04 | — | — | CN | claimed |
| CN-115297863-A | Topical pharmaceutical compositions comprising imidazo [1,2-b ] pyridazine compounds | 博善人工智能生物科技有限公司 | 2022-11-04 | — | — | CN | claimed |
| CN-112805062-B | Imidazo [1,2-b ] pyridazines as Trk inhibitors | 博善人工智能生物科技有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-115297863-A | Topical pharmaceutical compositions comprising imidazo [1,2-b ] pyridazine compounds | 博善人工智能生物科技有限公司 | 2022-11-04 | — | — | CN | disclosed |