Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004757 | 0.84 | L3MBTL1 (0.55) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15160536 | 0.73 | ALDH1A1 (0.44) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19273236 | 0.70 | MAPT (0.38) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9031375 | 0.70 | ADORA2A (0.54) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12862571 | 0.70 | HRH3 (0.41) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9031368 | 0.70 | ADORA2A (0.54) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3528891 | 0.70 | ADORA2A (0.40) | L3MBTL1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19540314 | 0.69 | HPGD (0.50) | L3MBTL1MAPTALDH1A1POLB | |
| SCHEMBL1155938 | 0.69 | SMN1; SMN2 (0.47) | L3MBTL1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL3433947 | 0.69 | SMN1; SMN2 (0.47) | L3MBTL1MAPTKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076660-A1 | USES OF ANTI-TGF-BETA ANTIBODIES AND CHECKPOINT INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2022-10-26 | — | — | EP | disclosed |