Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23612353 | 1.00 | MAPT (0.46) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL11118149 | 0.79 | SMN1; SMN2 (0.50) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL13910134 | 0.74 | ALDH1A1 (0.52) | MAPTALDH1A1TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL13730638 | 0.73 | SMN1; SMN2 (0.51) | MAPTALDH1A1TDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL11160019 | 0.73 | MAPT (0.54) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL15227310 | 0.73 | MAPT (0.54) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL3859690 | 0.73 | MAPT (0.43) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL13698355 | 0.73 | EGFR (0.47) | MAPTMCL1AHRSAE1UBA2 | |
| SCHEMBL26661128 | 0.72 | ICAM1 (0.39) | MAPTALDH1A1HTTPOLBLMNA | |
| SCHEMBL30656235 | 0.72 | ICAM1 (0.39) | MAPTALDH1A1HTTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085059-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF PROGRAMMED NECROSIS PATHWAY, COMPOSITION AND METHOD USING THE SAME | Accro Bioscience (HK) Limited (HK) | 2022-11-09 | — | — | EP | disclosed |