Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1013432 | 0.84 | ALDH1A1 (0.50) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL13267282 | 0.81 | TSHR (0.54) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL263757 | 0.79 | ALDH1A1 (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL25168575 | 0.77 | ALDH1A1 (0.58) | ALDH1A1TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL13267271 | 0.77 | ALDH1A1 (0.58) | ALDH1A1TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL1927983 | 0.76 | LTA4H (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL30206304 | 0.76 | LTA4H (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL263756 | 0.76 | LTA4H (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL23146340 | 0.76 | LTA4H (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 | |
| SCHEMBL1927517 | 0.76 | LTA4H (0.49) | LTA4HALDH1A1TSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133900-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090286789-A1 | Bi-Aryl Meta-Pyrimidine Inhibitors of Kinases | TARGEGEN, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20070191405-A1 | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286789-A1 | Bi-Aryl Meta-Pyrimidine Inhibitors of Kinases | JAK2, TYK2, LTK | LTA4H 626/4885ALDH1A1 3662/4885TSHR 1587/4885 |
| US-20070191405-A1 | Bi-aryl meta-pyrimidine inhibitors of kinases | JAK2, TYK2, JAK3 | LTA4H 3846/4885ALDH1A1 3235/4885TSHR 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.