Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | GABRP | O00591 | 1/20 | 0.56 |
| ▸ | GABRD | O14764 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.56 |
| ▸ | GABRE | P78334 | 1/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17078809 | 1.00 | MEN1 (0.57) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL16139291 | 0.87 | MGLL (0.55) | MEN1KMT2AALDH1A1MAPTFFAR1 | |
| SCHEMBL21329860 | 0.86 | GAA (0.66) | MEN1KMT2AALDH1A1MAPTCRHBP | |
| SCHEMBL3275588 | 0.85 | ACKR3 (0.59) | MEN1KMT2AALDH1A1FFAR1HTT | |
| SCHEMBL17078698 | 0.84 | MGLL (0.52) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1196240 | 0.84 | MGLL (0.53) | MEN1KMT2AFFAR1MGLLFAAH | |
| SCHEMBL599832 | 0.83 | CYP2C9 (0.67) | MEN1KMT2AFFAR1MGLLFAAH | |
| SCHEMBL25371894 | 0.81 | CYP2C9 (0.50) | FFAR1MGLLFAAHSMN1; SMN2 | |
| SCHEMBL5343522 | 0.81 | MMP13 (0.75) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL30229644 | 0.81 | CCR1 (0.55) | MEN1KMT2AMAPTFFAR1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12428413-B2 | Rho kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| EP-3990442-B1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20220388998-A1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12428413-B2 | Rho kinase inhibitors and compositions and methods of use thereof | ROCK1, ROCK2, RHOA | MEN1 3651/4885KMT2A 2778/4885ALDH1A1 4692/4885 |
| US-20220388998-A1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | ROCK1, ROCK2, RHOA | MEN1 3651/4885KMT2A 2778/4885ALDH1A1 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.