Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 2/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MUSK | O15146 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28651365 | 1.00 | SORT1 (0.48) | SORT1SCN10AHDAC4HDAC6RET | |
| SCHEMBL28669416 | 0.88 | SORT1 (0.45) | SORT1SCN10AHDAC4HDAC6RET | |
| SCHEMBL30065594 | 0.88 | SORT1 (0.45) | SORT1SCN10AHDAC4HDAC6RET | |
| SCHEMBL28928647 | 0.85 | SORT1 (0.62) | SORT1SCN10AHDAC4HDAC6 | |
| SCHEMBL30065536 | 0.85 | SORT1 (0.62) | SORT1SCN10AHDAC4HDAC6 | |
| SCHEMBL22942187 | 0.83 | SCN8A (0.49) | SORT1SCN10A | |
| SCHEMBL22941942 | 0.81 | SORT1 (0.58) | SORT1SCN10AHDAC4HDAC6RET | |
| SCHEMBL22942186 | 0.80 | SCN8A (0.47) | SORT1SCN10AKDRRAF1MET | |
| SCHEMBL22203188 | 0.80 | BRAF (0.38) | SCN10AKDRBRAF | |
| SCHEMBL29435940 | 0.80 | BRAF (0.38) | SCN10AKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112996774-B | 2-oxo-1,2-dihydropyridine derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |