Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | BRAF | P15056 | 5/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MUSK | O15146 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28669416 | 1.00 | SORT1 (0.45) | SORT1SCN10APROKR1HDAC4HDAC6 | |
| SCHEMBL30065560 | 0.88 | SORT1 (0.48) | SORT1SCN10AHDAC4HDAC6KDR | |
| SCHEMBL28651365 | 0.88 | SORT1 (0.48) | SORT1SCN10AHDAC4HDAC6KDR | |
| SCHEMBL22942053 | 0.85 | SORT1 (0.45) | SORT1SCN10APROKR1KDRBRAF | |
| SCHEMBL28668984 | 0.81 | TP53 (0.38) | — | |
| SCHEMBL30065779 | 0.81 | TP53 (0.38) | — | |
| SCHEMBL28658960 | 0.80 | SCN8A (0.49) | SCN10A | |
| SCHEMBL30065550 | 0.80 | SCN8A (0.49) | SCN10A | |
| SCHEMBL28921338 | 0.78 | SORT1 (0.54) | SORT1SCN10APROKR1HDAC4HDAC6 | |
| SCHEMBL22941942 | 0.78 | SORT1 (0.58) | SORT1SCN10AHDAC4HDAC6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112996774-B | 2-oxo-1,2-dihydropyridine derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |