Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.64 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168988 | 0.81 | CYP11B1 (0.69) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL13907295 | 0.80 | CYP11B1 (0.89) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL30067026 | 0.80 | NR1H4 (0.47) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL9049676 | 0.79 | CYP11B1 (1.00) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL8396472 | 0.79 | CYP11B1 (0.67) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL20547652 | 0.78 | CYP11B1 (0.66) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL30099869 | 0.78 | CYP11B1 (0.66) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL9200139 | 0.77 | CYP11B1 (0.64) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL7672864 | 0.76 | CYP11B1 (0.75) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 | |
| SCHEMBL12203767 | 0.76 | CYP11B1 (1.00) | CYP11B1CYP11B2HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250041319-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC | 2025-02-06 | — | — | US | disclosed |
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | RIBOSCIENCE LLC (US) | 2024-07-09 | — | — | US | disclosed |
| US-20220362266-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250041319-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | ENPP1, ENPP3, SMPD1 | CYP11B1 119/4885CYP11B2 158/4885HTT 3298/4885 |
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | ENPP1, ENPP3, SMPD1 | CYP11B1 127/4885CYP11B2 166/4885HTT 3278/4885 |
| US-20220362266-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | ENPP1, ENPP3, SMPD1 | CYP11B1 127/4885CYP11B2 166/4885HTT 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.