Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.69 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.69 |
| ▸ | TNF | P01375 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13907295 | 0.87 | CYP11B1 (0.89) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL7672864 | 0.83 | CYP11B1 (0.75) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL31357411 | 0.82 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL230002 | 0.82 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL22533781 | 0.81 | LTA4H (0.45) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL22533208 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL22533680 | 0.81 | LTA4H (0.45) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL22533622 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL29424731 | 0.81 | CYP11B1 (0.55) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL30067082 | 0.81 | CYP11B1 (0.64) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3952995-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | Riboscience LLC (US) | 2022-02-16 | — | — | EP | claimed |
| CN-114040915-A | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | 里伯赛恩斯有限责任公司 | 2022-02-11 | — | — | CN | claimed |
| WO-2020210649-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC (US) | 2020-10-15 | — | — | WO | claimed |
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | RIBOSCIENCE LLC (US) | 2024-07-09 | — | — | US | disclosed |
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | RIBOSCIENCE LLC (US) | 2024-07-09 | — | — | US | disclosed |
| EP-4249070-A2 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | Riboscience LLC (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3952995-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | Riboscience LLC (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-114040915-A | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | 里伯赛恩斯有限责任公司 | 2022-02-11 | — | — | CN | disclosed |
| WO-2020210649-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2020210649-A1 | BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS | RIBOSCIENCE LLC (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2010009029-A2 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010009029-A2 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | CYP3A5, CYP3A7, CYP11B1 | CYP11B1 3/4885CYP11B2 5/4885TNF 4467/4885 |
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | ENPP1, ENPP3, SMPD1 | CYP11B1 127/4885CYP11B2 166/4885TNF 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.