Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.65 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15472559 | 0.92 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL11410287 | 0.87 | GAA (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL18806401 | 0.87 | PDK2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL29434886 | 0.85 | HNF4A (0.66) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL21590157 | 0.85 | SLC6A4 (0.66) | CHRNB2CHRNA4CHRNB4CHRNA3GAA | |
| SCHEMBL28085560 | 0.85 | HNF4A (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL27577620 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL7016554 | 0.84 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL15074688 | 0.84 | KAT6A (0.59) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 | |
| SCHEMBL29854234 | 0.84 | HNF4A (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072850-B | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2023-07-21 | — | — | CN | claimed |
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | Pathios Therapeutics Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| CN-114835599-B | Preparation method of o-aryl benzamide compound | 绍兴久孚新材料科技有限公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-4253367-A1 | NOVEL BENZAZEPINE SPIRO DERIVATIVE | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2023-10-04 | — | — | EP | disclosed |
| CN-110072850-B | 3-sulfonyl-5-aminopyridine-2, 4-diol APJ agonists | 百时美施贵宝公司 | 2023-07-21 | — | — | CN | disclosed |
| US-20230130980-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS | TECHFIELDS PHARMA CO., LTD. (CN) | 2023-04-27 | — | — | US | disclosed |
| CN-114835599-A | Preparation method of o-aryl benzamide compound | 绍兴久孚新材料科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-20220073508-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2022-03-10 | — | — | US | disclosed |
| US-20180222921-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS | PREMIER RESEARCH INTERNATIONAL, LLC | 2018-08-09 | — | — | US | disclosed |
| CN-105073745-B | glucosylceramide synthase inhibitors | 建新公司 | 2018-06-29 | — | — | CN | disclosed |
| US-7488752-B2 | nor-seco himbacine derivatives; thrombosis, anticoagulants, anticancer agents; antiinflammatory agents; anticholesterol agents; cardiovascular disorders; antiarrhythmia agents; antiischemic agents; strokes; antiarthritic agents | SCHERING CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| CN-1121859-C | Process for preparing pharmaceutical composition for treatment or prevention hypertension | SNAKYO CO LTD (JP) | 2003-09-24 | — | — | CN | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |
| US-6015925-A | TREATING MYCOSIS | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-01-18 | — | — | US | disclosed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |
| CN-1192729-A | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-09-09 | — | — | CN | disclosed |
| CN-1188645-A | Process for preparing pharmaceutical composition for treatment or prevention hypertension | SNAKYO CO LTD (JP) | 1998-07-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368173-A1 | TRICYCLIC GPR65 MODULATORS | GPR65, GPR3, NR1H2 | CHRNB2 147/4885CHRNA4 150/4885CHRNB4 158/4885 |
| US-20180222921-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS | SLC7A1, VIP, HPGDS | CHRNB2 4750/4885CHRNA4 4880/4885CHRNB4 4828/4885 |
| US-20230130980-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS | SLC7A1, VIP, HPGDS | CHRNB2 4750/4885CHRNA4 4880/4885CHRNB4 4828/4885 |
| US-20220073508-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GBA1, GBA2, GAA | CHRNB2 4559/4885CHRNA4 4613/4885CHRNB4 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.