SCHEMBL30079142

SCHEMBL30079142

Cn1cc(CNC2CCN(C(=O)OC(C)(C)C)CC2)c(N)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
EPHX1 P07099 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
CCNA2 P20248 1/20 0.41
CDK2 P24941 1/20 0.41
GPR119 Q8TDV5 4/20 0.41
PTPN2 P17706 1/20 0.41
PTPN1 P18031 1/20 0.41
PTPN6 P29350 1/20 0.41
DPP4 P27487 1/20 0.41
EPHX2 P34913 1/20 0.41
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30079605 0.96 EPHX1 (0.46) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL30079299 0.94 SCN9A (0.45) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL30079238 0.86 ALDH1A1 (0.45) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL30079591 0.80 ALDH1A1 (0.42) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL31184445 0.79 KDM4E (0.53) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL2604335 0.79 KDM4E (0.53) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL23536067 0.77 KDM4E (0.48) ALDH1A1MAPTHTTGPR119PTPN2
SCHEMBL24895521 0.77 ALDH1A1 (0.47) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL17803256 0.75 USP30 (0.48) ALDH1A1EPHX1L3MBTL1NPC1MAPT
SCHEMBL2102000 0.75 ALDH1A1 (0.57) ALDH1A1EPHX1L3MBTL1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3737684-B1 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES IDORSIA PHARMACEUTICALS LTD (CH) 2022-11-16 EP disclosed