Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30079238 | 0.85 | ALDH1A1 (0.45) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL30079142 | 0.80 | ALDH1A1 (0.44) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL2102000 | 0.79 | ALDH1A1 (0.57) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL17140284 | 0.78 | ALDH1A1 (0.42) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL27182163 | 0.78 | ALDH1A1 (0.43) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL16463677 | 0.77 | EPHX2 (0.43) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL17140268 | 0.77 | ALDH1A1 (0.43) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL30079605 | 0.77 | EPHX1 (0.46) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL5012643 | 0.77 | ALDH1A1 (0.58) | ALDH1A1EPHX1MAPTL3MBTL1NPC1 | |
| SCHEMBL16463566 | 0.76 | GPR119 (0.44) | ALDH1A1MAPTL3MBTL1NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |