Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640273 | 0.81 | DGAT1 (0.39) | DGAT1 | |
| SCHEMBL3635281 | 0.79 | DGAT1 (0.35) | MAPTDGAT1 | |
| SCHEMBL2083830 | 0.74 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL4015092 | 0.72 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL1126058 | 0.70 | LMNA (0.45) | LMNAKMT2ADGAT1CYP2C19 | |
| SCHEMBL3528522 | 0.70 | DGAT1 (0.36) | DGAT1 | |
| SCHEMBL1395957 | 0.70 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15122465 | 0.70 | FGFR1 (0.48) | ALDH1A1KDM4ELMNAMAPTHTT | |
| SCHEMBL16100391 | 0.70 | NSD2 (0.37) | DGAT1 | |
| SCHEMBL25252035 | 0.69 | ALDH1A1 (0.57) | ALDH1A1LMNAKMT2ADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737684-B1 | 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-11-16 | — | — | EP | disclosed |