Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.34 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083469 | 0.90 | GPR39 (0.41) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30872090 | 0.89 | KCNN3 (0.38) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30083440 | 0.86 | CSNK2A2 (0.38) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30083523 | 0.86 | KCNN3 (0.44) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL24791511 | 0.83 | CDK7 (0.50) | CDK2GSK3BCDK7DPP4 | |
| SCHEMBL24793440 | 0.80 | CDK7 (0.54) | CDK2GSK3BCDK7 | |
| SCHEMBL30872099 | 0.79 | KCNN3 (0.39) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30083382 | 0.78 | GPR39 (0.48) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30083404 | 0.78 | KCNN3 (0.47) | KCNN3KDM4EMAPTNPC1RAB9A | |
| SCHEMBL30872083 | 0.77 | KCNN3 (0.49) | KCNN3NPC1RAB9AKMT2ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |