Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.37 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.37 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083401 | 0.87 | GSK3B (0.45) | CDK2GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL30083382 | 0.86 | GPR39 (0.48) | GPR39CDK2GSK3BKCNN3KCNN1 | |
| SCHEMBL30872083 | 0.83 | KCNN3 (0.49) | CDK2GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL30083599 | 0.83 | GSK3B (0.40) | CDK2GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL24792823 | 0.83 | CDK7 (0.55) | GPR39CDK2GSK3BRETPIM1 | |
| SCHEMBL30083523 | 0.83 | KCNN3 (0.44) | GPR39CDK2GSK3BKCNN3KCNN1 | |
| SCHEMBL22413144 | 0.81 | KCNN3 (0.48) | CDK2GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL30083621 | 0.80 | KCNN3 (0.41) | GPR39CDK2GSK3BKCNN3KCNN1 | |
| SCHEMBL30083450 | 0.80 | KCNN3 (0.43) | CDK2GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL24792389 | 0.79 | CDK7 (0.58) | GPR39CDK2GSK3BCDK8P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940427-A | Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof | 卡里克治疗有限公司 | 2024-04-26 | — | — | CN | disclosed |
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |