Sugi Predict

Sugi Predict / Compounds / SCHEMBL3008399

SCHEMBL3008399

SCHEMBL3008399

Cc1cccc(C(N)=O)c1[AsH]c1nc(Nc2ccc3c(c2)C(C)(C)CCC(=O)N3)ncc1Cl

nearest known ligand 0.65

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 14/20 0.65
▸ INSR P06213 12/20 0.60
▸ SYK P43405 2/20 0.39
▸ MAPK9 P45984 2/20 0.39
▸ MAPK10 P53779 2/20 0.39
▸ PTK2 Q05397 1/20 0.38
▸ GRM5 P41594 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2061959 0.85 MET (0.84) METINSR
SCHEMBL3008394 0.84 MET (0.61) METINSRSYKMAPK9MAPK10
SCHEMBL3008387 0.82 MET (0.74) METINSR
SCHEMBL3009987 0.82 MET (0.58) METINSRSYKPTK2
SCHEMBL3009983 0.79 MET (0.61) METINSRPTK2
SCHEMBL886721 0.79 MET (0.75) METINSR
SCHEMBL886149 0.79 MET (1.00) METINSR
SCHEMBL3014426 0.77 INSR (0.44) METINSRMAPK9MAPK10PTK2
SCHEMBL886466 0.75 MET (0.82) METINSR
SCHEMBL886325 0.75 MET (1.00) METINSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222647-A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS Cephalon, Inc. (US) 2010-09-01 — — EP disclosed
WO-2008051547-A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS CEPHALON, INC. (US) 2008-05-02 — — WO disclosed