Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.61 |
| ▸ | INSR | P06213 | 13/20 | 0.61 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3008387 | 0.90 | MET (0.74) | METINSRULK1ALK | |
| SCHEMBL886640 | 0.86 | MET (0.82) | METINSRULK1ALK | |
| SCHEMBL2939477 | 0.84 | MET (0.77) | METINSRULK1ALK | |
| SCHEMBL886145 | 0.82 | MET (0.80) | METINSRULK1ALK | |
| SCHEMBL3008399 | 0.79 | MET (0.65) | METINSRPTK2 | |
| SCHEMBL3008394 | 0.79 | MET (0.61) | METINSRPTK2 | |
| SCHEMBL3009987 | 0.77 | MET (0.58) | METINSRPTK2 | |
| SCHEMBL3005088 | 0.76 | MET (0.51) | METINSRULK1PTK2 | |
| SCHEMBL886710 | 0.76 | MET (1.00) | METINSRULK1PTK2ALK | |
| SCHEMBL2061757 | 0.76 | MET (0.85) | METINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |