SCHEMBL30086015

SCHEMBL30086015

CNC(=O)c1ccc(-c2cn3c(n2)sc2cc(C(=O)NC4[C@H]5CN(C(=O)OC(C)(C)C)C[C@@H]45)ccc23)cc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 5/20 0.54
▸ TP53 P04637 2/20 0.54
▸ POLB P06746 1/20 0.54
▸ MAPT P10636 6/20 0.53
▸ ALDH1A1 P00352 3/20 0.53
▸ KDM4E B2RXH2 2/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ ATM Q13315 1/20 0.53
▸ HPGD P15428 2/20 0.52
▸ THRB P10828 3/20 0.52
▸ RXFP1 Q9HBX9 3/20 0.52
▸ ALOX15 P16050 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29924997 0.88 MAPT (0.62) LMNATP53POLBMAPTALDH1A1
SCHEMBL29924958 0.88 MAPT (0.69) LMNATP53POLBMAPTALDH1A1
SCHEMBL29925301 0.87 LMNA (0.51) LMNATP53POLBMAPTALDH1A1
SCHEMBL29924760 0.87 LMNA (0.61) LMNATP53POLBMAPTALDH1A1
SCHEMBL29925371 0.87 LMNA (0.56) LMNATP53POLBMAPTALDH1A1
SCHEMBL24741792 0.83 LMNA (0.61) LMNATP53POLBMAPTALDH1A1
SCHEMBL30085892 0.83 LMNA (0.61) LMNATP53POLBMAPTALDH1A1
SCHEMBL24619787 0.83 LMNA (0.61) LMNATP53POLBMAPTALDH1A1
SCHEMBL29925232 0.82 LMNA (0.50) LMNATP53POLBMAPTALDH1A1
SCHEMBL24741290 0.81 LMNA (0.67) LMNATP53POLBMAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-11-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 LMNA 1484/4885TP53 96/4885POLB 1476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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