Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.58 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.52 |
| ▸ | ULK1 | O75385 | 5/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754901 | 1.00 | MAPK8 (0.58) | MAPK8PKMYT1ALKMETTAS2R14 | |
| SCHEMBL23754819 | 0.91 | MAPK8 (0.59) | MAPK8PKMYT1ULK1PTK2EGFR | |
| SCHEMBL30086254 | 0.91 | MAPK8 (0.59) | MAPK8PKMYT1ULK1PTK2EGFR | |
| SCHEMBL23754918 | 0.90 | MAPK8 (0.57) | MAPK8PKMYT1ALKMETULK1 | |
| SCHEMBL30086216 | 0.90 | MAPK8 (0.57) | MAPK8PKMYT1ALKMETULK1 | |
| SCHEMBL23764855 | 0.90 | MAPK8 (0.61) | MAPK8PKMYT1ALKMETULK1 | |
| SCHEMBL30086370 | 0.90 | MAPK8 (0.61) | MAPK8PKMYT1ALKMETULK1 | |
| SCHEMBL30086246 | 0.84 | ULK1 (0.59) | MAPK8PKMYT1ALKULK1CDC7 | |
| SCHEMBL23754825 | 0.84 | ULK1 (0.59) | MAPK8PKMYT1ALKULK1CDC7 | |
| SCHEMBL1039207 | 0.83 | GLO1 (0.55) | MAPK8ALKMETULK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515589-A | ULK1/2 inhibitors and methods of use thereof | 萨克生物研究学院 | 2022-12-23 | — | — | CN | disclosed |
| EP-4103182-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Salk Institute for Biological Studies (US) | 2022-12-21 | — | — | EP | disclosed |