Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28600207 | 1.00 | DYRK1A (0.39) | DYRK1AXDHKDM1AGPR35EGLN2 | |
| SCHEMBL21921428 | 0.77 | XDH (0.37) | XDHGPR35EGLN2PGRCACNA1H | |
| SCHEMBL7092888 | 0.73 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYP1A2 | |
| SCHEMBL28604998 | 0.73 | RXFP1 (0.35) | DYRK1AKDM1AGPR35PGRALDH1A1 | |
| SCHEMBL30088006 | 0.70 | XDH (0.46) | DYRK1AXDHKDM1AGPR35ALDH1A1 | |
| SCHEMBL28601707 | 0.70 | XDH (0.46) | DYRK1AXDHKDM1AGPR35ALDH1A1 | |
| SCHEMBL11172727 | 0.68 | ALDH1A1 (0.49) | DYRK1AKDM1AGPR35ALDH1A1SMN1; SMN2 | |
| SCHEMBL14025078 | 0.68 | POLB (0.53) | DYRK1AKDM1AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28977558 | 0.67 | CXCR2 (0.50) | DYRK1AKDM1AGPR35ALDH1A1SMN1; SMN2 | |
| SCHEMBL3552549 | 0.67 | DYRK1A (0.47) | DYRK1AKDM1AEGLN2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | GENENTECH, INC. (US) | 2025-01-28 | — | — | US | disclosed |
| US-20220370420-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | HIPK1, NEK1, HIPK2 | DYRK1A 1225/4885XDH 2184/4885KDM1A 1706/4885 |
| US-20220370420-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | HIPK1, NEK1, HIPK2 | DYRK1A 1225/4885XDH 2184/4885KDM1A 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.