Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29167964 | 0.81 | UCHL3 (0.41) | KDM4EMAPTCCR5MAPK1PTPN11 | |
| SCHEMBL28413821 | 0.74 | AKR1C3 (0.42) | ALDH1A1MAPTCYP2C19GAAKMT2A | |
| SCHEMBL3597395 | 0.73 | KEAP1 (0.53) | HPGDKDM4ECCR5PKMHSD17B10 | |
| SCHEMBL30087761 | 0.73 | DYRK1A (0.39) | ALDH1A1HPGDKDM4EMAPTMAOA | |
| SCHEMBL28600207 | 0.73 | DYRK1A (0.39) | ALDH1A1HPGDKDM4EMAPTMAOA | |
| SCHEMBL21644638 | 0.72 | AKR1C3 (0.44) | ALDH1A1KDM4EMAPTPOLBCYP2C19 | |
| SCHEMBL19706710 | 0.70 | SMN1; SMN2 (0.52) | ALDH1A1HPGDKDM4EMAOAPOLB | |
| SCHEMBL30082300 | 0.70 | NR4A1 (0.46) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL932002 | 0.70 | NR4A1 (0.46) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL1093499 | 0.70 | LMNA (0.44) | ALDH1A1KDM4EMAPTPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325011-A2 | METHODS AND COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028861-A2 | METHODS AND COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2002-04-11 | — | — | WO | disclosed |