Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28899159 | 1.00 | MAPT (0.44) | MAPTTP53LMNAROCK2ROCK1 | |
| SCHEMBL14915956 | 0.78 | MAPK8 (0.52) | MAPTTP53LMNAALDH1A1 | |
| SCHEMBL4678834 | 0.77 | MEN1 (0.46) | MAPTTP53LMNAMAPK10ALDH1A1 | |
| SCHEMBL15010499 | 0.77 | MAPK8 (0.47) | MAPTTP53LMNACMA1PARK7 | |
| SCHEMBL2315834 | 0.76 | MMP13 (0.64) | ROCK2ROCK1HDAC1HDAC2HDAC6 | |
| SCHEMBL31381672 | 0.76 | MAPK10 (0.49) | MAPTTP53LMNAMAPK10ALDH1A1 | |
| SCHEMBL19679824 | 0.76 | MAPK10 (0.52) | MAPTTP53LMNAMAPK10ALDH1A1 | |
| SCHEMBL28899220 | 0.74 | LMNA (0.43) | MAPTTP53LMNAMAPK10ALDH1A1 | |
| SCHEMBL30095522 | 0.74 | LMNA (0.43) | MAPTTP53LMNAMAPK10ALDH1A1 | |
| SCHEMBL30283377 | 0.74 | EGLN1 (0.45) | MAPTTP53MAPK10ALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |