Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095522 | 1.00 | LMNA (0.43) | LMNANPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL30095463 | 0.80 | BRD4 (0.40) | LMNANPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL28899157 | 0.80 | BRD4 (0.40) | LMNANPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL28899155 | 0.77 | RAB9A (0.48) | LMNANPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL28899159 | 0.74 | MAPT (0.44) | LMNATP53MAPK10ALDH1A1HDAC1 | |
| SCHEMBL30095433 | 0.74 | MAPT (0.44) | LMNATP53MAPK10ALDH1A1HDAC1 | |
| SCHEMBL28321534 | 0.72 | HDAC3 (0.62) | TSHRTP53POLBHTTALDH1A1 | |
| SCHEMBL14915956 | 0.68 | MAPK8 (0.52) | LMNATSHRTP53ALDH1A1MAPT | |
| SCHEMBL15010499 | 0.67 | MAPK8 (0.47) | LMNATP53HDAC1HDAC2HDAC6 | |
| SCHEMBL19679824 | 0.66 | MAPK10 (0.52) | LMNATP53BRD4KDM4EMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-109456308-A | Heterocyclic compound and its application as ASK inhibitor | 南京圣和药业股份有限公司 | 2019-03-12 | — | — | CN | disclosed |