Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NPM1 | P06748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497704 | 1.00 | NOS1 (0.39) | NOS1METAP2CSNK2A1CYP2A6CYP11B1 | |
| SCHEMBL20423421 | 0.79 | HSD17B1 (0.42) | CYP11B1CYP11B2KDM4EMEN1ALDH1A1 | |
| SCHEMBL20975068 | 0.79 | CYP11B2 (0.37) | CYP2A6CYP11B1CYP11B2MAPTBACE1 | |
| SCHEMBL30804194 | 0.79 | NOS1 (0.37) | NOS1METAP2CSNK2A1CYP2A6CYP11B1 | |
| SCHEMBL29709757 | 0.79 | NOS1 (0.37) | NOS1CYP2A6DYRK1ACHUKACHE | |
| SCHEMBL4306327 | 0.79 | CYP1A2 (0.41) | CYP2A6KDM4EALDH1A1BACE1ACHE | |
| SCHEMBL4064559 | 0.79 | NOS1 (0.37) | NOS1CYP2A6DYRK1ACHUKACHE | |
| SCHEMBL13172306 | 0.79 | ERN1 (0.43) | NOS1METAP2CSNK2A1CYP2A6CYP11B1 | |
| SCHEMBL28716125 | 0.79 | NOS1 (0.37) | NOS1METAP2CSNK2A1CYP2A6CYP11B1 | |
| SCHEMBL30572689 | 0.79 | NPM1 (0.39) | NOS1METAP2CSNK2A1CYP2A6CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612294-B | Human cerebulin ligands and bifunctional compounds comprising same | 阿尔维纳斯运营股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-115974840-A | Human cereblon ligand and bifunctional compound comprising same | 阿尔维纳斯运营股份有限公司 | 2023-04-18 | — | — | CN | disclosed |
| WO-2022251359-A1 | BICYCLIC INHIBITORS OF ALK5 AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-12-01 | — | — | WO | disclosed |