Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.44 |
| ▸ | ULK1 | O75385 | 5/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23674939 | 1.00 | MAP4K1 (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL31329494 | 0.88 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL21646064 | 0.88 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL31329495 | 0.88 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL23674722 | 0.85 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100726 | 0.85 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100712 | 0.85 | ULK1 (0.53) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL26088019 | 0.85 | ULK1 (0.53) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL23674800 | 0.85 | KIF11 (0.43) | CRBNKIF11ALDH1A2ULK1CYP1A2 | |
| SCHEMBL30100690 | 0.85 | KIF11 (0.43) | CRBNKIF11ALDH1A2ULK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4093400-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | The Trustees of Princeton University (US) | 2022-11-30 | — | — | EP | disclosed |