Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30103057 | 0.85 | RECQL (0.51) | RECQLKMOLMNASMN1; SMN2MAPT | |
| SCHEMBL30103077 | 0.83 | KMO (0.47) | GRM2RECQLKMOCYP2C9LMNA | |
| SCHEMBL9917342 | 0.81 | KMO (0.57) | RECQLKMOERBB2EGFRHDAC8 | |
| SCHEMBL30017917 | 0.80 | GRIN2B (0.47) | GRM2CYP2C9 | |
| SCHEMBL30017776 | 0.79 | QPCT (0.47) | GRM2CYP2C9CYP11B1CYP11B2 | |
| SCHEMBL24784526 | 0.78 | GRM2 (0.43) | GRM2CYP2C9LMNASMN1; SMN2MEN1 | |
| SCHEMBL30017915 | 0.78 | GRM2 (0.43) | GRM2CYP2C9LMNASMN1; SMN2MEN1 | |
| SCHEMBL24784529 | 0.74 | KMT2A (0.45) | GRM2CYP2C9SMN1; SMN2MEN1MAPT | |
| SCHEMBL30103018 | 0.73 | KMO (0.47) | RECQLKMOCYP2C9CYP11B1CYP11B2 | |
| SCHEMBL1135534 | 0.72 | RECQL (0.77) | GRM2RECQLKMOLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448913-A | Bicyclic compounds for the treatment of EP2, EP4 receptor mediated diseases | 武汉人福创新药物研发中心有限公司 | 2022-12-09 | — | — | CN | disclosed |