SCHEMBL30103299

SCHEMBL30103299

O=c1c2cc(Cl)ccc2nc(Nc2cccnc2)n1-c1ccccc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43
TUBA3C P0DPH7 1/20 0.43
TUBA1B P68363 1/20 0.43
TUBA4A P68366 1/20 0.43
TUBB4B P68371 1/20 0.43
TUBB3 Q13509 1/20 0.43
TUBB2A Q13885 1/20 0.43
TUBB8 Q3ZCM7 1/20 0.43
TUBA3E Q6PEY2 1/20 0.43
TUBA1A Q71U36 1/20 0.43
TUBA1C Q9BQE3 1/20 0.43
TUBB6 Q9BUF5 1/20 0.43
TUBB2B Q9BVA1 1/20 0.43
TUBB1 Q9H4B7 1/20 0.43
CYP19A1 P11511 1/20 0.42
ALPL P05186 1/20 0.42
CYP11B2 P19099 1/20 0.42
RAD52 P43351 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24110936 1.00 TUBB4A (0.43) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23958267 0.91 WEE1 (0.46) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30103295 0.91 WEE1 (0.46) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23064706 0.90 TUBB4A (0.46) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL30103212 0.89 TDO2 (0.48) RAD52KMT2A
SCHEMBL23958205 0.89 TDO2 (0.48) RAD52KMT2A
SCHEMBL30025728 0.88 TUBB4A (0.45) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23958278 0.88 TUBB4A (0.45) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23958210 0.85 GPR6 (0.41) CYP11B2RAD52KMT2ALMNA
SCHEMBL23958262 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115427399-A 2-heteroarylaminoquinazolinone derivatives 住友制药株式会社 2022-12-02 CN claimed
CN-115427399-A 2-heteroarylaminoquinazolinone derivatives 住友制药株式会社 2022-12-02 CN disclosed