Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23705000 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3804288 | 0.84 | ALDH1A1 (0.43) | ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL18467822 | 0.84 | ALDH1A1 (0.43) | ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL27386798 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7268276 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3542040 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL1654271 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL21876707 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL21877046 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1EPHX2CYP2C19TSHR | |
| SCHEMBL102373 | 0.82 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1EPHX2CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |