Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30018345 | 0.89 | ALDH1A1 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL26981157 | 0.88 | ALDH1A1 (0.53) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL31584318 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14725908 | 0.87 | ALDH1A1 (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30103368 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18244688 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17822795 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL31631006 | 0.85 | ALDH1A1 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL26689658 | 0.84 | KDM4A (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17229458 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4097138-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | Avila Therapeutics, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021155317-A1 | ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2021-08-05 | — | — | WO | disclosed |