Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28741968 | 0.95 | SIGMAR1 (0.56) | SIGMAR1MAOAMAOBKMT2ABCHE | |
| SCHEMBL29712033 | 0.92 | KMT2A (0.56) | RXFP1SIGMAR1MAOAMAOBKMT2A | |
| SCHEMBL29711994 | 0.88 | SIGMAR1 (0.57) | RXFP1SIGMAR1MAOAMAOBKMT2A | |
| SCHEMBL29640447 | 0.85 | RXFP1 (0.56) | RXFP1SIGMAR1MAOAMAOBKMT2A | |
| SCHEMBL29712062 | 0.84 | KMT2A (0.54) | MAOAMAOBKMT2A | |
| SCHEMBL22966101 | 0.84 | ACHE (0.47) | KMT2ABCHEACHESLC6A12MEN1 | |
| SCHEMBL29640165 | 0.83 | POLB (0.57) | SIGMAR1MAOAMAOBKMT2AMEN1 | |
| SCHEMBL24771759 | 0.82 | SIGMAR1 (0.56) | SIGMAR1MAOAMAOBBCHEACHE | |
| SCHEMBL29640441 | 0.82 | SIGMAR1 (0.56) | SIGMAR1MAOAMAOBBCHEACHE | |
| SCHEMBL22966092 | 0.81 | POLB (0.50) | RXFP1SIGMAR1MAOAMAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (FR) | 2022-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | HTT, NTRK2, BDNF | RXFP1 1822/4885SIGMAR1 1243/4885MAOA 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.