SCHEMBL30104720

SCHEMBL30104720

Cc1ccc(C(C)(C)C)cc1C1CC2(CCN(C(=O)OC(C)(C)C)CC2)C1

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 5/20 0.59
GPR119 Q8TDV5 6/20 0.45
ACACB O00763 5/20 0.44
NAMPT P43490 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23867968 1.00 MGLL (0.59) MGLLGPR119ACACBNAMPT
SCHEMBL23867886 0.89 MGLL (0.58) MGLLGPR119NAMPT
SCHEMBL30104728 0.89 MGLL (0.58) MGLLGPR119NAMPT
SCHEMBL29470013 0.88 MGLL (0.54) MGLLGPR119ACACBNAMPT
SCHEMBL23868007 0.88 MGLL (0.54) MGLLGPR119ACACBNAMPT
SCHEMBL23868042 0.88 MGLL (0.61) MGLLGPR119NAMPT
SCHEMBL30104745 0.88 MGLL (0.61) MGLLGPR119NAMPT
SCHEMBL23867964 0.85 MGLL (0.62) MGLLGPR119NAMPT
SCHEMBL30104729 0.85 MGLL (0.62) MGLLGPR119NAMPT
SCHEMBL23868049 0.83 MGLL (0.53) MGLLGPR119ACACBNAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115362153-A Aza spiro rings as monoacylglycerol lipase modulators 詹森药业有限公司 2022-11-18 CN disclosed