Evolitrine

Evolitrine

SCHEMBL30105705

COc1ccc2c(OC)c3ccoc3nc2c1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 11/20 0.67
TUBB4A P04350 1/20 0.67
TUBB P07437 1/20 0.67
TUBA3C P0DPH7 1/20 0.67
TUBA1B P68363 1/20 0.67
TUBA4A P68366 1/20 0.67
TUBB4B P68371 1/20 0.67
TUBB3 Q13509 1/20 0.67
TUBB2A Q13885 1/20 0.67
TUBB8 Q3ZCM7 1/20 0.67
TUBA3E Q6PEY2 1/20 0.67
TUBA1A Q71U36 1/20 0.67
TUBA1C Q9BQE3 1/20 0.67
TUBB6 Q9BUF5 1/20 0.67
TUBB2B Q9BVA1 1/20 0.67
TUBB1 Q9H4B7 1/20 0.67
ALDH1A1 P00352 10/20 0.55
HPGD P15428 7/20 0.55
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Confusameline SCHEMBL21784044 0.84 KDM4E (0.65) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Confusameline SCHEMBL30525089 0.84 KDM4E (0.65) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Kokusaginine SCHEMBL23870280 0.80 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Kokusaginine SCHEMBL30609976 0.80 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Dictamnine SCHEMBL1760700 0.80 POLB (0.65) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Maculine SCHEMBL29461401 0.75 KDM4E (0.66) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Maculine SCHEMBL30361505 0.75 KDM4E (0.66) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12466681 0.74 KDM1A (0.47) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL31214315 0.74 ALDH1A1 (0.66) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12466494 0.71 PHLPP2 (0.53) KDM4ETUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12310952-B2 Traditional Chinese drug monomer composition for treating Helicobacter pylori, preparation method and use thereof YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITIES (CN) 2025-05-27 US claimed
US-20240316013-A1 TRADITIONAL CHINESE DRUG MONOMER COMPOSITION FOR TREATING HELICOBACTER PYLORI, PREPARATION METHOD AND USE THEREOF YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITES (CN) 2024-09-26 US claimed
US-20260034186-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2026-02-05 US disclosed
US-12427176-B2 Enriched mineral pitch resin products and methods of manufacturing enriched mineral pitch resin products RIZUN NODARI (US) 2025-09-30 US disclosed
US-12310952-B2 Traditional Chinese drug monomer composition for treating Helicobacter pylori, preparation method and use thereof YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITIES (CN) 2025-05-27 US disclosed
US-12310952-B2 Traditional Chinese drug monomer composition for treating Helicobacter pylori, preparation method and use thereof YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITIES (CN) 2025-05-27 US disclosed
US-20240316013-A1 TRADITIONAL CHINESE DRUG MONOMER COMPOSITION FOR TREATING HELICOBACTER PYLORI, PREPARATION METHOD AND USE THEREOF YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITES (CN) 2024-09-26 US disclosed
US-20240316013-A1 TRADITIONAL CHINESE DRUG MONOMER COMPOSITION FOR TREATING HELICOBACTER PYLORI, PREPARATION METHOD AND USE THEREOF YOUJIANG MEDICAL UNIVERSITY FOR NATIONALITES (CN) 2024-09-26 US disclosed
US-20240216457-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2024-07-04 US disclosed
US-20240216456-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2024-07-04 US disclosed
US-20240207344-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2024-06-27 US disclosed
US-20240207342-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2024-06-27 US disclosed
US-20240108676-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2024-04-04 US disclosed
US-11883454-B2 Enriched mineral pitch resin products and methods of manufacturing enriched mineral pitch resin products RIZUN NODARI (US) 2024-01-30 US disclosed
US-20230405067-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2023-12-21 US disclosed
US-20220387537-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS RIZUN NODARI (US) 2022-12-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260034186-A1 ENRICHED MINERAL PITCH RESIN PRODUCTS AND METHODS OF MANUFACTURING ENRICHED MINERAL PITCH RESIN PRODUCTS TRPV1, SOST, RUNX1 KDM4E 2069/4885TUBB4A 2451/4885TUBB 2860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.