Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.32 |
| ▸ | SELE | P16581 | 8/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.32 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30107362 | 0.80 | RAF1 (0.35) | RAF1PLK1MKNK1MKNK2GAA | |
| SCHEMBL20518840 | 0.80 | RAF1 (0.35) | RAF1PLK1MKNK1MKNK2GAA | |
| SCHEMBL30107341 | 0.73 | AOC1 (0.35) | — | |
| SCHEMBL20519828 | 0.71 | NPC1 (0.39) | RAF1PLK1ICAM1SELEMKNK1 | |
| SCHEMBL365712 | 0.69 | PLK1 (0.45) | PLK1NUDT1 | |
| SCHEMBL2005686 | 0.65 | SIRT3 (0.38) | RAF1PLK1MKNK1MKNK2GAA | |
| SCHEMBL28365334 | 0.65 | PTPN1 (0.35) | — | |
| SCHEMBL30600890 | 0.65 | PTPN1 (0.35) | — | |
| SCHEMBL23898681 | 0.64 | ATM (0.43) | GAA | |
| SCHEMBL17490727 | 0.62 | LCK (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678466-B | Diazanaphthalenes as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |