⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376483 | 1.00 | — | — | |
| SCHEMBL1657424 | 0.81 | CHRM2 (0.30) | — | |
| SCHEMBL25903452 | 0.79 | — | — | |
| SCHEMBL17992172 | 0.76 | CHRNB2 (0.32) | — | |
| SCHEMBL19812849 | 0.75 | — | — | |
| SCHEMBL27861797 | 0.75 | — | — | |
| SCHEMBL17311209 | 0.75 | — | — | |
| SCHEMBL31662642 | 0.74 | SLC7A5 (0.32) | — | |
| SCHEMBL20627076 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL52415 | 0.71 | CTSK (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4633681-A1 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Merck Sharp & Dohme LLC (US) | 2025-10-22 | — | — | EP | disclosed |
| EP-4596550-A1 | COMPOUND USABLE IN CONJUGATION REACTION AND CONJUGATE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024114528-A9 | COMPOUND USABLE IN CONJUGATION REACTION AND CONJUGATE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2024-10-03 | — | — | WO | disclosed |
| EP-4433095-A1 | PEPTIDE CONJUGATES OF PEPTIDIC TUBULIN INHIBITORS AS THERAPEUTICS | Cybrexa 4, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| US-20240252665-A1 | CHEMICAL COUPLING LINKER AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2024-08-01 | — | — | US | disclosed |
| WO-2024129628-A1 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024114528-A1 | COMPOUND USABLE IN CONJUGATION REACTION AND CONJUGATE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2024-06-06 | — | — | WO | disclosed |
| EP-4349372-A1 | ANTIBODY DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| EP-4349832-A1 | CHEMICAL COUPLING LINKER AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| CN-116615411-A | Process for producing peptide compound containing N-substituted amino acid residue | 中外制药株式会社 | 2023-08-18 | — | — | CN | disclosed |
| WO-2023091957-A1 | PEPTIDE CONJUGATES OF PEPTIDIC TUBULIN INHIBITORS AS THERAPEUTICS | CYBREXA 4, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2022253035-A1 | ANTIBODY DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253033-A1 | CHEMICAL COUPLING LINKER AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-12-08 | — | — | WO | disclosed |