Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13988083 | 0.84 | LMNA (0.68) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8276416 | 0.82 | LMNA (0.65) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3031824 | 0.82 | LMNA (1.00) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL5282314 | 0.81 | LMNA (0.74) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL14058601 | 0.79 | HDAC3 (0.73) | LMNASMN1; SMN2ALDH1A1KMT2AMAPT | |
| SCHEMBL4867633 | 0.79 | HDAC3 (0.90) | LMNASMN1; SMN2ALDH1A1HDAC3HDAC4 | |
| SCHEMBL27180731 | 0.77 | LMNA (0.72) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL13988046 | 0.76 | SMN1; SMN2 (0.67) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4732936 | 0.76 | MAPT (0.69) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8276031 | 0.76 | HDAC3 (0.62) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053995-A1 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-03 | — | — | US | claimed |
| WO-2008061247-A2 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENT OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | claimed |
| US-9316633-B2 | Methods for identifying inhibitors of solute transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-19 | — | — | US | disclosed |
| US-20110053995-A1 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053995-A1 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053995-A1 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-03 | — | — | US | disclosed |
| US-20100190796-A1 | METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2008061247-A2 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENT OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008061247-A2 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENT OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190796-A1 | METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS | SLC2A1, SLC2A3, SLC2A8 | LMNA 3138/4885SMN1; SMN2 4776/4885ALDH1A1 3404/4885 |
| US-20110053995-A1 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS | SLC14A1, SLC2A1, SLC2A4 | LMNA 3349/4885SMN1; SMN2 4662/4885ALDH1A1 1500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.