Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522456 | 0.83 | ALDH1A1 (1.00) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3010847 | 0.81 | LMNA (0.69) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3031824 | 0.81 | LMNA (1.00) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31681418 | 0.80 | LMNA (0.70) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4732970 | 0.79 | LMNA (0.79) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3021651 | 0.79 | ALDH1A1 (0.66) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15705429 | 0.79 | LMNA (0.85) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10079157 | 0.78 | GFER (0.78) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13988083 | 0.78 | LMNA (0.68) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30150630 | 0.78 | KMT2A (0.64) | LMNAALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | LMNA 851/4885ALDH1A1 781/4885SMN1; SMN2 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.