Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16771271 | 0.86 | FOLH1 (0.49) | FOLH1GSRRNPEPCPB2SIRT6 | |
| SCHEMBL43995 | 0.86 | FOLH1 (0.66) | FOLH1GSRRNPEPCPB2CA1 | |
| SCHEMBL11524220 | 0.86 | FOLH1 (0.47) | FOLH1HPGDSGSRRNPEPCPB2 | |
| SCHEMBL9875634 | 0.86 | FOLH1 (0.66) | FOLH1GSRRNPEPCPB2CA1 | |
| SCHEMBL43996 | 0.86 | FOLH1 (0.66) | FOLH1GSRRNPEPCPB2CA1 | |
| SCHEMBL13697774 | 0.84 | HPGDS (0.49) | FOLH1HPGDSGSRRNPEPCPB2 | |
| SCHEMBL17613291 | 0.83 | HPGDS (0.43) | FOLH1HPGDSGSRRNPEPCPB2 | |
| SCHEMBL32675730 | 0.82 | HPGDS (0.48) | FOLH1HPGDSGSRRNPEPSIRT6 | |
| SCHEMBL11896083 | 0.82 | SIRT6 (0.56) | FOLH1HPGDSGSRSIRT6SIRT1 | |
| SCHEMBL726302 | 0.82 | SIRT6 (0.56) | FOLH1HPGDSGSRSIRT6SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426327-A2 | COMPLEMENT INHIBITOR DOSING REGIMENS | Apellis Pharmaceuticals, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023129496-A9 | RNAS FOR COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| WO-2024148274-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| WO-2023081318-A2 | COMPLEMENT INHIBITOR DOSING REGIMENS | APELLIS PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023278698-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| EP-4087541-A1 | TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA | Apellis Pharmaceuticals, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |