Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188200 | 1.00 | AURKA (0.53) | AURKABRD4NAMPTMEN1POLB | |
| SCHEMBL21799092 | 0.90 | TRPV1 (0.51) | AURKAMEN1POLBKMT2AGSK3A | |
| SCHEMBL30114784 | 0.89 | AURKA (0.58) | AURKA | |
| SCHEMBL20188503 | 0.89 | AURKA (0.58) | AURKA | |
| SCHEMBL20188007 | 0.89 | AURKA (0.45) | AURKA | |
| SCHEMBL20188270 | 0.88 | — | — | |
| SCHEMBL30114704 | 0.88 | — | — | |
| SCHEMBL20188248 | 0.88 | AURKA (0.60) | AURKAKMT2A | |
| SCHEMBL20188249 | 0.86 | AURKA (0.59) | AURKANAMPTMEN1KMT2A | |
| SCHEMBL30114720 | 0.86 | CDK2 (0.52) | AURKAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | claimed |
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | disclosed |