Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | FES | P07332 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639216 | 1.00 | TGFBR1 (0.41) | TGFBR1KCNH2PIK3C3NOTUMLRRK2 | |
| SCHEMBL15639201 | 0.96 | TGFBR1 (0.40) | TGFBR1KCNH2PIK3C3NOTUMLRRK2 | |
| SCHEMBL22753045 | 0.86 | TGFBR1 (0.38) | TGFBR1KCNH2PIK3C3LRRK2PIK3CA | |
| SCHEMBL30117430 | 0.85 | TGFBR1 (0.58) | TGFBR1ROCK2AKT1PIM1GSK3B | |
| SCHEMBL15639428 | 0.85 | TGFBR1 (0.58) | TGFBR1ROCK2AKT1PIM1GSK3B | |
| SCHEMBL15639535 | 0.82 | GSK3B (0.44) | TGFBR1PIK3C3ROCK2AKT1PIM1 | |
| SCHEMBL15639548 | 0.81 | TGFBR1 (0.44) | TGFBR1PIK3C3AKT1CDK2PIK3CA | |
| SCHEMBL15640001 | 0.81 | RIPK1 (0.44) | TGFBR1PIK3C3AKT1PIM1GSK3B | |
| SCHEMBL30117454 | 0.81 | RIPK1 (0.44) | TGFBR1PIK3C3AKT1PIM1GSK3B | |
| SCHEMBL15639938 | 0.79 | TGFBR1 (0.39) | TGFBR1PIK3C3ROCK2AKT1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |