Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 11/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | PRKCG | P05129 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | AKT2 | P31751 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639428 | 1.00 | TGFBR1 (0.58) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL15640023 | 0.86 | TGFBR1 (0.70) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL15639216 | 0.85 | TGFBR1 (0.41) | TGFBR1GSK3BROCK2PIM1CDK5 | |
| SCHEMBL30117442 | 0.85 | TGFBR1 (0.41) | TGFBR1GSK3BROCK2PIM1CDK5 | |
| SCHEMBL15638173 | 0.85 | ROCK2 (0.43) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL15637893 | 0.83 | CDK5 (0.44) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL19817532 | 0.83 | TGFBR1 (0.40) | TGFBR1 | |
| SCHEMBL15638757 | 0.83 | TGFBR1 (0.61) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL15639308 | 0.81 | TGFBR1 (0.60) | TGFBR1TRPA1GSK3BROCK2PIM1 | |
| SCHEMBL15639248 | 0.81 | TGFBR1 (0.60) | TGFBR1TRPA1GSK3BROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |