Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.52 |
| ▸ | EIF2AK3 | Q9NZJ5 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.50 |
| ▸ | EIF2AK1 | Q9BQI3 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | HCK | P08631 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24650671 | 1.00 | RIPK1 (0.52) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651094 | 0.94 | RIPK1 (0.52) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120724 | 0.94 | RIPK1 (0.52) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30486107 | 0.93 | RIPK1 (0.54) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24650624 | 0.93 | RIPK1 (0.54) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24650646 | 0.89 | RIPK1 (0.61) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120809 | 0.89 | RIPK1 (0.61) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24651167 | 0.88 | EIF2AK3 (0.53) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL24650626 | 0.87 | EIF2AK3 (0.50) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 | |
| SCHEMBL30120857 | 0.87 | EIF2AK3 (0.50) | RIPK1EIF2AK3CYP3A4EIF2AK2EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-11-21 | — | — | US | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | NEK7, NEK11, NEK2 | RIPK1 537/4885EIF2AK3 2387/4885CYP3A4 2703/4885 |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | RIPK1 20/4885EIF2AK3 1310/4885CYP3A4 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.