Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.57 |
| ▸ | RXRB | P28702 | 9/20 | 0.57 |
| ▸ | RXRG | P48443 | 9/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308545 | 1.00 | RXRA (0.57) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL287631 | 0.86 | RXRA (0.61) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL12500917 | 0.85 | RXRA (0.75) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL4811433 | 0.84 | NR3C2 (0.46) | RXRARXRBRXRGNR3C2P2RX7 | |
| SCHEMBL12984838 | 0.84 | NR3C2 (0.52) | NR3C2P2RX7EPHX1PTPN7DUSP3 | |
| SCHEMBL6213644 | 0.84 | P2RX7 (0.47) | NR3C2P2RX7EPHX1PTPN7DUSP3 | |
| Hydrochloric Acid SCHEMBL1373105 | 0.84 | RXRA (0.59) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL1567847 | 0.83 | NR3C2 (0.51) | NR3C2 | |
| SCHEMBL30151151 | 0.83 | NR3C2 (0.51) | NR3C2 | |
| SCHEMBL12672486 | 0.81 | P2RX7 (0.45) | NR3C2P2RX7EPHX1PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116368112-A | Novel potassium channel inhibitors | 萨尼奥纳有限责任公司 | 2023-06-30 | — | — | CN | disclosed |
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |