Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 16/20 | 0.59 |
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.55 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NEK4 | P51957 | 1/20 | 0.55 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.55 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.55 |
| ▸ | MERTK | Q12866 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24651066 | 1.00 | RIPK1 (0.59) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL25793432 | 0.89 | RIPK1 (0.48) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL30120809 | 0.87 | RIPK1 (0.61) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL24650646 | 0.87 | RIPK1 (0.61) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL30120799 | 0.84 | RIPK1 (0.48) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL24650631 | 0.84 | RIPK1 (0.48) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL24650695 | 0.82 | EIF2AK3 (0.47) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL30120848 | 0.82 | EIF2AK3 (0.47) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL30120757 | 0.82 | RIPK1 (0.49) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 | |
| SCHEMBL24650623 | 0.82 | RIPK1 (0.49) | RIPK1EIF2AK3CYP3A4CYP2C9EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-11-21 | — | — | US | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| WO-2022212326-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382488-A1 | NEK7 INHIBITORS | NEK7, NEK11, NEK2 | RIPK1 537/4885EIF2AK3 2387/4885CYP3A4 2703/4885 |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | RIPK1 20/4885EIF2AK3 1310/4885CYP3A4 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.