Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22639010 | 1.00 | MYC (0.38) | MYCKMT2ATRPA1MEN1LMNA | |
| Water SCHEMBL23070689 | 0.98 | MYC (0.37) | MYCKMT2ATRPA1MEN1LMNA | |
| SCHEMBL3644471 | 0.88 | HPGD (0.40) | MYCKMT2ACYP3A4CYP2C9HSD17B10 | |
| SCHEMBL29869399 | 0.88 | HPGD (0.40) | MYCKMT2ACYP3A4CYP2C9HSD17B10 | |
| SCHEMBL1443195 | 0.88 | HPGD (0.40) | MYCKMT2ACYP3A4CYP2C9HSD17B10 | |
| SCHEMBL248670 | 0.88 | HPGD (0.40) | MYCKMT2ACYP3A4CYP2C9HSD17B10 | |
| SCHEMBL28195204 | 0.75 | CES2 (0.44) | KMT2AMEN1TDP1ALDH1A1HPGD | |
| SCHEMBL28127994 | 0.75 | ALDH1A1 (0.47) | CYP1A2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL2722029 | 0.75 | HPGD (0.43) | KMT2AHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL7181728 | 0.75 | HPGD (0.43) | KMT2AHSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572252-A | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2023-01-06 | — | — | CN | disclosed |