Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014074 | 0.80 | MEN1 (0.41) | KMT2AMEN1NOTUMALDH1A1PKM | |
| SCHEMBL3006586 | 0.80 | MEN1 (0.41) | KMT2AMEN1NOTUMALDH1A1PKM | |
| SCHEMBL2997925 | 0.80 | MEN1 (0.41) | KMT2AMEN1NOTUMALDH1A1PKM | |
| SCHEMBL13266813 | 0.76 | HTR7 (0.44) | HTR7KMT2AMEN1HCAR1ACACB | |
| SCHEMBL3008916 | 0.76 | HTR7 (0.48) | HTR7KMT2AMEN1P2RX7PKM | |
| SCHEMBL2998069 | 0.76 | HTR2C (0.34) | HTR7KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3003057 | 0.74 | L3MBTL1 (0.40) | KMT2AMEN1HCAR1NOTUMALDH1A1 | |
| SCHEMBL3001942 | 0.74 | HTR7 (0.44) | HTR7KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3010180 | 0.73 | CCR1 (0.42) | ADAMTS5ALDH1A1NPC1RAB9A | |
| SCHEMBL3002692 | 0.72 | L3MBTL1 (0.50) | KMT2AMEN1NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | claimed |
| EP-1608655-B8 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | BRANE DISCOVERY SRL IN LIQUIDA (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | claimed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | claimed |
| EP-1608655-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2005-12-28 | — | — | EP | claimed |
| WO-2004085438-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2004-10-07 | — | — | WO | claimed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| EP-1608655-B8 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | BRANE DISCOVERY SRL IN LIQUIDA (IT) | 2008-10-15 | — | — | EP | disclosed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| EP-1608655-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004085438-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | GRIN3B, GRIN3A, GRIN1 | HTR7 151/4885KMT2A 3610/4885MEN1 3691/4885 |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | OPRL1, GRIN3B, GRIN3A | HTR7 109/4885KMT2A 4169/4885MEN1 3590/4885 |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | GRIN3A, GRIN1, GRIN3B | HTR7 189/4885KMT2A 4212/4885MEN1 4719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.