Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014074 | 1.00 | MEN1 (0.41) | MEN1KMT2AMAPTPKMCYP3A4 | |
| SCHEMBL3006586 | 1.00 | MEN1 (0.41) | MEN1KMT2AMAPTPKMCYP3A4 | |
| SCHEMBL2998069 | 0.83 | HTR2C (0.34) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3001942 | 0.81 | HTR7 (0.44) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3008916 | 0.80 | HTR7 (0.48) | MEN1KMT2APKM | |
| SCHEMBL3012380 | 0.80 | HTR7 (0.46) | MEN1KMT2APKMALDH1A1KDM4E | |
| SCHEMBL2997939 | 0.80 | NOTUM (0.44) | KMT2AALDH1A1NOTUMHPGD | |
| SCHEMBL3003057 | 0.78 | L3MBTL1 (0.40) | MEN1KMT2AMAPTCYP3A4ALDH1A1 | |
| SCHEMBL3006535 | 0.78 | NOTUM (0.36) | NOTUMDDB1CRBN | |
| SCHEMBL2996862 | 0.78 | MGLL (0.38) | MEN1KMT2AALDH1A1ALOX5NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | claimed |
| EP-1608655-B8 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | BRANE DISCOVERY SRL IN LIQUIDA (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | claimed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | claimed |
| EP-1608655-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2005-12-28 | — | — | EP | claimed |
| WO-2004085438-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2004-10-07 | — | — | WO | claimed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2010-07-08 | — | — | US | disclosed |
| US-7732473-B2 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | NEUROTUNE AG (CH) | 2010-06-08 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| EP-1608655-B8 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | BRANE DISCOVERY SRL IN LIQUIDA (IT) | 2008-10-15 | — | — | EP | disclosed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
| EP-1608655-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004085438-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173945-A1 | Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof | GRIN3B, GRIN3A, GRIN1 | MEN1 3691/4885KMT2A 3610/4885MAPT 866/4885 |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | OPRL1, GRIN3B, GRIN3A | MEN1 3590/4885KMT2A 4169/4885MAPT 1530/4885 |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | GRIN3A, GRIN1, GRIN3B | MEN1 4719/4885KMT2A 4212/4885MAPT 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.